Modeling and Analysis in PK/PD with ADAPT

7th Computational Pharmacy Workshop 17-18 September 2015 Kraków, Poland

Modeling and Analysis in PK/PD with ADAPT

7th Computational Pharmacy Workshop 17-18 September 2015 Kraków, Poland

The workshop is intended for basic and clinical researchers involved with the application of modeling, simulation and data analysis to problems involving drug kinetics and drug response. The workshop will include Background Lectures on mathematical, statistical, and computational aspects of pharmacokinetic/pharmacodynamic modeling, with an emphasis on the principles and applications of simulation and estimation methods, as well as in vitro-in vivo extrapolation in PK/ PD. Case Studies will focus on the application of the ADAPT software to modeling problems and will involve hands- on computer work covering the following topics:

  • pharmacokinetic/pharmacodynamic modeling;
  • least squares and maximum likelihood estimation;
  • Bayesian estimation;
  • estimation with multiple response models;
  • PBPK & recirculatory models;
  • population modeling.
The workshop will give the participants an exposure to the broad class of PK/PD modeling problems that can be solved using ADAPT.

Laptop computers are required to participate in case studies. No special software is needed, and all ADAPT examples will be made available as stand-alone executable programs. ADAPT is made freely available through the Biomedical Simulations Resource at the University of Southern California, which is supported by the Bioengineering Program of the National Institute for Biomedical Imaging and Bioengineering at the NIH (P41-EB001978).