Modeling and Analysis in PK/PD with ADAPT

7th Computational Pharmacy Workshop 17-18 September 2015 Kraków, Poland

Modeling and Analysis in PK/PD with ADAPT

7th Computational Pharmacy Workshop 17-18 September 2015 Kraków, Poland

Thursday, 17 September 2015

8:30 Introductions and Overview
8:45 Background: Modeling with ADAPT
9:30 Case Study: Model Building (SIM)
10:15 Break
10:30 Background: Individual Estimation Fundamentals
11:15 Case Study: WLS/ML Estimation (ID)
12:15 Lunch
1:15 Case Study: Direct Response PK/PD Models (ID)
2:00 Case Study: Indirect Response PK/PD Models (ID)
2:45 Break
3:00 Case Study: Extravascular Absorption PK (ID)
3:45 Case Study: Metabolite Modeling (ID)
4:30 Recap, Looking Forward, Adjourn

Friday, 18 September 2015

8:30 Background: In Vitro-In Vivo Extrapolation of the Drug Cardiac Effect
8.50 Background: PharmML & SO – Encoding Standards for Exchange of Models and Results in Pharmacometrics
9:30 Case Study: Recirculatory Models of Drug Disposition (ID)
10:15 Break
10:30 Case Study: PBPK Modeling (SIM)
11:15 Background: Population Modeling Fundamentals
12:00 Lunch
1:00 Case Study: Population PK Example (MLEM)
1:45 Case Study: Population PK/PD Example (MLEM)
2:30 Case Study: Population Modeling with Covariates (MLEM)
3:15 Final Q&A and Discussion
3:30 Adjourn